Cardiotoxicity reduction induced by halofantrine entrapped in nanocapsule devices
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چکیده
منابع مشابه
Cardiotoxicity reduction induced by halofantrine entrapped in nanocapsule devices.
The main objective of the present study was to evaluate the reduction in halofantrine (Hf) toxicity, an antimalarial drug frequently associated with QT interval prolongation in electrocardiogram, by its entrapment in poly-epsilon-caprolactone nanocapsules (NC). The acute lethal dose (LD(100)) of Hf.HCl experimentally observed was 200 mg/kg whereas the calculated LD(50) was 154 mg/kg. In contras...
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ژورنال
عنوان ژورنال: Life Sciences
سال: 2007
ISSN: 0024-3205
DOI: 10.1016/j.lfs.2006.12.019